Potential of amentoflavone with antiviral properties in COVID-19 treatment

Abstract Amentoflavone is one of the flavonoids that are known for their antiviral effects and many them predicted to have inhibitory against severe acute respiratory syndrome coronavirus (SARS-CoV) Middle East Coronavirus (MERS-CoV) enzymes 3-chymotrypsin-like protease (3CLpro) papain-like (PLpro). a biflavonoid found in herbal extracts St. John's wort ( Hypericum perforatum ), Gingko biloba , Selaginella tamariscina, Torreya nucifera other plants. Its pharmacological actions been listed as antiviral, antibacterial, antioxidant, anti-inflammatory, antidiabetic, antidepressant, neuroprotective. Molecular docking studies amentoflavone binds strongly active site main (M pro ) coronavirus-2 (SARS-CoV-2). As conventional medications met with limited success disease-2019 (COVID-19) vaccines only weapons COVID-19 pharmaceutical armamentarium, traditional medicines being considered forefront battle COVID-19. Clinical extract additional or alternative drugs/supplements registered. Here we review potential amentoflavone, an agent both adjunct therapy sepsis preventive could provide protection “cytokine storm.” Compared extracts, which induce cytochrome P450 (CYP) uridine 5′-diphospho (UDP)-glucuronosyltransferases (UGT) activity producing negative herb–drug interaction, potent inhibitor CYP3A4, CYP2C9, UGT. Further into therapeutic infection warranted.